The kids are all right: Children with 3-way DNA are healthy

first_img Both DNA-mixing procedures involve the mitochondria; the one that recently produced the baby was aimed at replacing a mother’s defective mitochondria. Cohen’s procedure injected a bit of mitochondria-containing cytoplasm into the mother’s egg.Genes in the mitochondrial DNA don’t affect traits like eye and hair color but are important for keeping cells healthy throughout the body.Cohen’s hospital performed the infertility treatment between 1996 and 2001 on 33 couples who failed to conceive after roughly five tries at in vitro fertilization.“We felt that there was something wrong with the cytoplasm” and that injecting a small amount of it from a healthy egg donor might aid embryo development, Cohen said.Fourteen of the 33 patients became pregnant, and 13 ultimately gave birth to 18 babies, including two sets of twins and one of quadruplets. (One of the 18 babies was a twin from a standard egg donation; doctors also included data on that child in the follow-up study.)Cohen and colleagues presented their findings Wednesday in the journal Reproductive BioMedicine Online.The parents of the quadruplets refused multiple requests for follow-up information; doctors know only that all four are alive and in high school.In detailed surveys, parents of the 14 other children all reported their kids in good health. One has chronic migraines, two have mild asthma, one is obese, seven have allergies, and one has attention deficit disorder. None of those rates are unusual for that number of children, doctors said. One boy was diagnosed with a borderline developmental disorder at 18 months but not when he was older, and he has an A average in school. More than 15 years ago, 17 babies were born after an experimental infertility treatment that gave them DNA from three people: Mom, Dad and an egg donor.Now researchers have checked up on how the babies are doing as teenagers. The preliminary verdict: The kids are all right.With no sign of unusual health problems and excellent grades in school at ages 13 to 18, these children are “doing well,” said embryologist Jacques Cohen of the Institute for Reproductive Medicine & Science at Saint Barnabas in Livingston, N.J., where the treatment was done.advertisement Privacy Policy Sperm test 2.0: New diagnostics aim to better understand male infertility Emma Foster (far right), is one of a handful of children born about 15 years ago from three sources of DNA. AP Photo/Richard Drew Related: So finding no problem so far from the infertility treatment is helpful and “a good message” for people considering the disease-prevention procedure, Cohen said. But he emphasized that his findings cannot be taken as proof that the newer procedure is safe and should be performed.Cells carry DNA in two places: the nucleus, where the chromosomes are, and to a much smaller degree the mitochondria. Mitochondria are the little powerhouses in the cytoplasm, the liquid part of the egg cell outside the nucleus. Please enter a valid email address. Leave this field empty if you’re human: “These children have done well,” Cohen said. “It’s what we expected or at least had hoped.”At least two other clinics in the United States. and several in other countries tried the technique after Cohen started it, but the US work stopped after the Food and Drug Administration stepped in to regulate it. Cohen said his group tried to comply with the FDA’s requirements for a permit to continue the work but lost funding before it could meet them.It’s not clear why the treatment worked for the 13 couples, Cohen said. One possibility is the infusion of mitochondria, but cytoplasm contains other molecules and structures too, he said.In any case, it was a success for Emma’s parents, Susan and Peter Foster, who had been trying for about seven years to have a baby.When Cohen’s experimental procedure was described to them and they were asked if they were interested, they had no doubts, Peter said.Susan gave birth at 33. Emma was healthy and has continued that way, her parents say.Emma is the only child in the survey to have been told about the procedure. She said she has long known her origins were unusual — her mom keeps a book that shows her as an embryo — but she didn’t know the specifics until recently.“I think it’s really cool,” she said. “It makes me different.” HealthThe kids are all right: Children with 3-way DNA are healthy Associated Press Beyond three-parent babies: New drugs offer hope for mitochondrial disease By Associated Press Oct. 26, 2016 Reprints Related: That includes Emma Foster, 17, of Red Bank, N.J. “I turned out normal,” Foster said in an interview Tuesday. A cheerleader since age 10, she is now looking at colleges and thinking of majoring in engineering.The infertility procedure is no longer performed. But the study of the children is timely because just last month, the first baby was born from a different procedure that also mixed genetic material from three people. That technique is aimed not at infertility but at preventing the child from inheriting harmful genes from the mother. Critics are concerned about its long-term safety.advertisement Newsletters Sign up for Daily Recap A roundup of STAT’s top stories of the day. About the Author Reprints She may no longer carry any trace of the donor. Only two of eight babies tested after birth showed any sign of donor mitochondria, and Emma was one who showed none. Cohen said the tests, which were not as sensitive then as now, might have overlooked some traces.The follow-up study has some limitations. It’s based on a survey of parents, and the accuracy of such second-hand information can be shaky. And it includes just 13 teens, with no comparison group.Still, Dr. James Grifo, director of infertility treatment at New York University, said the results suggest that criticism of research that mixes DNA from three people appears unfounded.“The outcomes looked uniformly good … suggesting that no harm was done,” said Grifo, who did not participate in the new study. The donor cytoplasm “certainly may have played a role in allowing their embryo to develop to a stage that allowed a pregnancy.”In 1999, after years of experiments in mice, Grifo and colleagues made embryos with DNA from three people and transferred them to several patients’ wombs, but no pregnancy resulted. Then the FDA stepped in and stopped the work.“I think it should be allowed,” Grifo said.But Dr. Alan Copperman, director of infertility at Mount Sinai School of Medicine in New York, said the jury is still out on whether using a third party’s genetic material is safe.“I don’t think that we’re yet able to declare victory and that we’ve figured out how to fix an unhealthy egg or embryo,” Copperman said. Most eggs that fail to develop normally, especially with older patients, are because of abnormal chromosomes, so tinkering with the cytoplasm is not likely to be a solution for many people, he said.But it apparently worked for the Fosters.Emma “is a blessing and a miracle,” Susan Foster said, “and medical science made that possible.”— Marilynn Marchione Tags designer babiesinfertilitymitochondrialast_img read more

Road-tripping the mountains of B.C. in the electric Porsche Taycan

first_img COMMENTSSHARE YOUR THOUGHTS At an elevation of 1,717m, the Pennask Summit of Highway 97C in the interior of British Columbia is more than a kilometre higher than the nearest city. To get there, you must go up. It’s mainly for this reason that whenever I drive the stretch of highway connecting the small city of Merritt, my hometown, with Kelowna and the Okanagan wine region, I always prepare for adventure. It’s the kind of Canadian highway that murders old cars, roasts brakes and tests the mettle of drivers from straighter, flatter places, leaving them stranded on the side of the road, climbing the oft-snowy banks of the ditches in search of a cell signal that isn’t there.RELATED Coleman Molnar Coleman Molnar Back at the fast-charging port at the base of the mountains, I had a chance to brush up on the car’s numbers: The Porsche Taycan 4S is the brand’s mid-tier EV option, positioned between the trim-topping Taycan Turbo S and the entry-level rear-wheel-drive Taycan. The 4S starts at $119,400 (compared to the Turbo S Cross Turismo’s MSRP of $218,000), and goes up as you add the bells and whistles like the Passenger Display screen that extends across the dash and allows whoever’s riding shotgun to control navigation, entertainment, or just access the “cockpit” screen and keep an eye on the vehicle’s real-time performance statistics.Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4S Created with Raphaël 2.1.2Created with Raphaël 2.1.2 Porsche Taycan 4S  Coleman Molnar Trending in Canada Coleman Molnar Coleman Molnar Car Review: 2021 Porsche Taycan 4S LISTEN: A Truck Guy’s take on the electrification of the pickup advertisement On the topic of performance stats, the Taycan 4S uses 2 permanent magnet synchronous motors, a 93.4 kWh lithium ion battery, and the Performance Battery Plus option in this model to produce 482 horsepower (562 in overboost) and 479 lb-ft of torque for all four tires, pushing the sedan to 100 km/h in 4.0 seconds with launch control activated. Exploring this last characteristic on a spirited drive around the Okanagan Lake’s north end earlier that day was likely what landed me in my highway predicament, but I regret nothing.Because when you’re behind the wheel of a car like the Taycan, your future self’s problems take a backseat and your focus goes to where it belongs: the road. The Taycan has the soul of a sports car and the looks to match. Its weight sits low, creating the same uber-grounded sense you get in a 911, even though the car weighs around 2,200 kg (4,894 lbs) compared to the 911’s relatively dainty 1,500 kg (3,300 lbs) average curb weight. On the ice and snow presented to me in the clouds high above the Okanagan valley, the car drives like it’s on a rail. Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4Scenter_img In retrospect, I probably could have avoided turning around and heading back down toward where I knew an appropriate charging port existed in the city of Kelowna, because once I’d tipped the Taycan’s nose downward and engaged the regenerative braking system, which executes up to 90 per cent of the car’s braking functions and can capture 265 kW compared to the average EV’s 80 kW, the predicted range held steady. Literally from the point I u-turned near the summit to the outskirts of the city some 50 km away, the range reading stayed the same. It’s science! And if you don’t believe me, just ask Bill Nye. This is a feature well worth its weight on the mountain routes of the BC Interior. Because any road trip in this part of the country – even the essential kinds that happen in the midst of a global pandemic – is bound to be a hilly one. Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4S But those physics also lead to a relatively modest range of 323 km, which my contact at the Porsche dealership says was just enough for him and a colleague to get from Kelowna in the province’s interior to the coast with range mode activated and all the power-stealing extras like AC on pause. The opposite of how I drove. After a week with the EV and several more (essential) trips up and down various mountain highways, followed by several more charges at high-speed EV stations, I conclude that this sedan is indeed the Ultimate BC Road Trip Machine. Sure, it lacks the toy-towing utility of a pickup truck, the spaciousness of an SUV, and more importantly the 500-plus-km range of a gas-sipping hatchback, but it climbs the steep BC hills like a rocket… a luxurious, leather lined rocket with a custom Bose sound system and two trunks. And up here in the sun above the clouds, it looks pretty alright, too.  Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4SColeman Molnar Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4SColeman Molnar Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4SColeman Molnar Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4SColeman Molnar Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4SColeman Molnar Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4SColeman Molnar Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4SColeman Molnar Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4SColeman Molnar Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4SColeman Molnar The Porsche Taycan is the world’s fastest car—indoors, that isAnd until as recently as December 2020, the route also didn’t have any fuel service for over a hundred kilometres, half of it uphill no matter which way you go. Now the new fuel station located between the two cities stands like a beacon on the mountain route, offering overconfident drivers a chance to eat their humble pie without having to double back after proclaiming that “yes, of course we’ll have enough gas to get there.” Subscribe for free to Plugged In on Apple Podcasts, Spotify, and Stitcher. First Look: 2022 Lexus NX The sport-cute’s looks have been softened, but its powertrains and infotainment offerings have been sharpened RELATED TAGSPorscheTaycanSedanLuxuryElectric CarsLuxury CarsElectric VehiclesLocal ContentLuxury VehiclesNew VehiclesRoad TripsTravelVancouverBritish ColumbialocalOkanaganRoad trip We encourage all readers to share their views on our articles using Facebook commenting Visit our FAQ page for more information. Coleman Molnar My problem as I drove ever upwards toward Pennask Summit and into the falling spring snow in the brand new electric 2020 Porsche Taycan 4S I’d been loaned by Porsche Canada via Porsche Centre Kelowna, was that I didn’t know whether the new gas station had a charging port. That, and I’d exuberantly devoured more than 50 per cent of the Taycan 4S’s range, which had read nearly 500 km when I’d picked it up earlier that day. And so the Okanagan Connector claimed another victim as I learned my first EV ownership lesson: always respect the range, especially when there are hills involved. Oops.Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4S Created with Raphaël 2.1.2Created with Raphaël 2.1.2Porsche Taycan 4S ‹ Previous Next ›last_img read more

Round 5: Pacquiao evades Vargas’ offense

first_imgLAS VEGAS, NV – NOVEMBER 05: (R-L) Manny Pacquiao of the Philippines fires a left at Jessie Vargas during their WBO welterweight championship fight at the Thomas & Mack Center on November 5, 2016 in Las Vegas, Nevada. Christian Petersen/Getty Images/AFPChampion Jessie Vargas tried to land two-punch combos on Manny Pacquiao’s defense but he failed to use his reach advantage this time.Vargas lunged at Pacquiao as he continued his two-punch combos but Pacquiao used his footwork to avoid being pinned on the ropes.ADVERTISEMENT EDITORS’ PICK Round 4: Vargas gets solid shot at Pacquiao Brad Pitt wins his first acting Oscar as awards get underway Don’t miss out on the latest news and information. FEATURED STORIESSPORTSGinebra teammates show love for SlaughterSPORTSWe are youngSPORTSCone plans to speak with Slaughter, agent PH among economies most vulnerable to virus 30 Filipinos from Wuhan quarantined in Capas Mainland China virus cases exceed 40,000; deaths rise to 908 Smart’s Siklab Saya: A multi-city approach to esports Where did they go? Millions left Wuhan before quarantine We are young MOST READ Sports Related Videospowered by AdSparcRead Next Taiwan minister boards cruise ship turned away by Japan PLAY LIST 01:31Taiwan minister boards cruise ship turned away by Japan01:33WHO: ‘Global stocks of masks and respirators are now insufficient’01:01WHO: now 31,211 virus cases in China 102:02Vitamin C prevents but doesn’t cure diseases like coronavirus—medic03:07’HINDI PANG-SPORTS LANG!’03:03SILIP SA INTEL FUND Chinese-manned vessel unsettles Bohol town Smart hosts first 5G-powered esports exhibition match in PH BREAKING: Solicitor General asks SC to forfeit ABS CBN’s franchise View commentslast_img read more